目的:探讨长期高脂饮食引起的胰岛素抵抗对pR5株系MAPT Tau转基因小鼠的认知功能和大脑Tau蛋白磷酸化的影响。方法:8周龄雌性pR5 M......

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Tau hyperphosphorylation plays a critical role in neurodegenerative diseases....

Objective Loss of synaptic spine has been considered the earliest events of cerebral ischemia and generally assumed to b......

One of pathological hallmarks of Alzheimers disease (AD) is neurofibrillary tangles (NFTs) consisting of abnormally hype......

Objective: To investigate the effects of lithium on cognitive function and metabolism of Amyloid-beta Protein Precursor ......

Helicobacter pylori (H.pylori) infection is a recognized risk factor of dementia,while its role and mechanism in Alzheim......